Article
Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2006
Juriloff Diana M, Harris Muriel J, McMahon Andrew P, Carroll Thomas J, Lidral Andrew C
Abstract excerpt
BACKGROUND: Nonsyndromic cleft lip (CL) with or without cleft palate (CLP) is a common human birth defect with complex genetic etiology. One of the unidentified genes maps to chromosome 17q21. A mouse strain, A/WySn, has CLP with complex genetic etiology that models the human defect, and 1 of its causative genes, clf1, maps to a region homologous to human 17q21. Extensive studies of the candidate region pointed...
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