Article
Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate.
Genomics - 1 Dec 1998
Yoshiura K, Machida J, Daack-Hirsch S, Patil S R, Ashworth L K, Hecht J T, Murray J C
Abstract excerpt
Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. Loci for nonsyn...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Chromosome Mapping
- Chromosomes, Human, Pair 19
- Chromosomes, Human, Pair 2
- Cleft Lip
- Cleft Palate
- Cloning, Molecular
- DNA Primers
- Humans
- Membrane Proteins
- Mice
- Molecular Sequence Data
- Pedigree
- RNA, Messenger