Arylamine <i>N</i>-Acetyltransferase Is Required for Synthesis of Mycolic Acids and Complex Lipids in <i>Mycobacterium bovis</i> BCG and Represents a Novel Drug Target

Abstract excerpt

Mycolic acids represent a major component of the unique cell wall of mycobacteria. Mycolic acid biosynthesis is inhibited by isoniazid, a key frontline antitubercular drug that is inactivated by mycobacterial and human arylamine N-acetyltransferase (NAT). We show that an in-frame deletion of Mycobacterium bovis BCG nat results in delayed entry into log phase, altered morphology, altered cell wall lipid...

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