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Article

Nestin Is a Potential Mediator of Malignancy in Human Neuroblastoma Cells

25 Jun 2004

Abstract excerpt

Amplification of the N-myc proto-oncogene signifies aggressive behavior in human neuroblastoma. Likewise, overexpression of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased aggressiveness in several nervous system tumors. We investigated the interaction of these two proteins in human neuroblastoma cells. Neuroblastic cell variants with high levels of N-Myc protein have...

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Identifiers

PMID: 15117961
DOI: 10.1074/jbc.m312663200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Nestin Is a Potential Mediator of Malignancy in Human Neuroblastoma CellsPMID 15117961Read ↗

Nestin expression in human tumors and tumor cell lines.Semantic proximity Read ↗

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Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.Semantic proximity Read ↗

Role of the Stem Cell-Associated Intermediate Filament Nestin in Malignant Proliferation of Non-Small Cell Lung CancerSemantic proximity Read ↗

Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20.Semantic proximity Read ↗

Modulation of N-myc expression alters the invasiveness of neuroblastomaSemantic proximity Read ↗

Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture.Semantic proximity Read ↗

Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.Semantic proximity Read ↗

Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in MiceSemantic proximity Read ↗

N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma.Semantic proximity Read ↗

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