Article
Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.
Scientific reports - 24 Apr 2017
Krüger Kristi, Wik Elisabeth, Knutsvik Gøril, Nalwoga Hawa, Klingen Tor A, Arnes Jarle B, Chen Ying, Mannelqvist Monica, Dimitrakopoulou Konstantina, Stefansson Ingunn M, Birkeland Even, Aas Turid, Tobin Nicholas P, Jonassen Inge, Bergh Jonas, Foulkes William D, Akslen Lars A
Abstract excerpt
We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n = 103), mRNA microarray data from TCGA (n = 520), METABRIC (n = 1992), and 6 open access breast...
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