Article
Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.
Cancer research - 15 Jul 1990
Schweigerer L, Breit S, Wenzel A, Tsunamoto K, Ludwig R, Schwab M
Abstract excerpt
Amplification and enhanced expression of the MYCN oncogene are thought to contribute to the development and progression of human neuroblastomas. Here, we have transfected human neuroblastoma cells that harbor a single MYCN gene copy with the human MYCN gene driven by a viral enhancer/promoter, and we have compared the properties of the parental and the transfected cells. The transfected cells show an enhanced...
Topics
- Animals
- Cell Division
- Clone Cells
- Culture Media
- DNA, Neoplasm
- Exons
- Fibroblast Growth Factors
- Gene Expression
- Humans
- Lipoproteins, HDL
- Mice