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Article

N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma.

European journal of biochemistry - 1 Aug 2002

Hatzi Elissavet, Murphy Carol, Zoephel Andreas, Ahorn Horst, Tontsch Ulrike, Bamberger Ana-Maria, Yamauchi-Takihara Keiko, Schweigerer Lothar, Fotsis Theodore

Abstract excerpt

Amplification of N-myc oncogene is a frequent event in advanced stages of human neuroblastoma and correlates with poor prognosis and enhanced neovascularization. Angiogenesis is an indispensable prerequisite for the progression and metastasis of solid malignancies, which is modulated by tumor suppressors and oncogenes. We have addressed the possibility that N-myc oncogene might regulate angiogenesis in...

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Source

Identifiers

PMID: 12153570
DOI: 10.1046/j.1432-1033.2002.03066.x

Genes

LIF
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma.PMID 12153570Read ↗

Paracrine Signaling Through MYCN Enhances Tumor-Vascular Interactions in NeuroblastomaSemantic proximity Read ↗

MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coinSemantic proximity Read ↗

Down‐regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cellsSemantic proximity Read ↗

Overexpression of N-Myc Rapidly Causes Acute Myeloid Leukemia in MiceSemantic proximity Read ↗

Inhibition of Phosphatidylinositol 3-Kinase Destabilizes Mycn Protein and Blocks Malignant Progression in NeuroblastomaSemantic proximity Read ↗

Angiogenesis in neuroblastoma.Semantic proximity Read ↗

Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYCSemantic proximity Read ↗

PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in NeuroblastomaSemantic proximity Read ↗

Modulation of N-myc expression alters the invasiveness of neuroblastomaSemantic proximity Read ↗

N-MYC Regulates Focal Adhesion Kinase Expression in Human NeuroblastomaSemantic proximity Read ↗

Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity.Semantic proximity Read ↗

N-Myc overexpression leads to decreased β1 integrin expression and increased apoptosis in human neuroblastoma cellsSemantic proximity Read ↗

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