Article
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.
The Journal of biological chemistry - 2 Jul 2004
Terui Yasuhito, Saad Natalie, Jia Shidong, McKeon Frank, Yuan Junying
Abstract excerpt
The nuclear import of nuclear factor of activated T cells (NFAT) transcription factors is critical for regulating NFAT activity. Here we demonstrate that the sumoylation of NFAT1 defines a novel mechanism of the nuclear anchorage and transcriptional activation downstream from the known mechanism of calcineurin-mediated dephosphorylation and nuclear import. We show that Lys(684) and Lys(897) of NFAT1 can be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.