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Article

Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction.

Thrombosis and haemostasis - 1 Dec 2005

Roldán Vanessa, Corral Javier, Marín Francisco, Pineda Javier, Vicente Vicente, González-Conejero Rocío

Abstract excerpt

Factor XII (FXII) plays a key role in both coagulation and fibrinolysis, thus its role in thrombotic processes is uncertain. Both genetic and environmental factors determine FXII plasma levels. A common C46T polymorphism in the Kozak region of F12 gene disturbs the translation of the protein leading to a significant reduction of FXII levels although its clinical significance is conflictive. We studied the F12...

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PMID: 16411408
DOI: 10.1160/TH05-06-0453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Synergistic association between hypercholesterolemia and the C46T factor XII polymorphism for developing premature myocardial infarction.PMID 16411408Read ↗

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