Article
New polymorphisms in the IL-10 promoter region.
Genes and immunity - 1 Feb 2000
D'Alfonso S, Rampi M, Rolando V, Giordano M, Momigliano-Richiardi P
Abstract excerpt
Interleukin-10 (IL-10) is an important immunoregulatory cytokine. We searched for new sequence variations in the 5' flanking region of the IL-10 gene by denaturing high performance liquid chromatography. A 3996 bp region spanning position -3934 to +61 was amplified in 12 polymerase chain reaction (PCR) fragments and each fragment was screened for variations in 23 Italian individuals. The following eight sequence...
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