Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.

Cell research - 1 Apr 2004

Oakley Cecily E, Hambly Brett D, Curmi Paul M G, Brown Louise J

Abstract excerpt

The muscle protein myosin binding protein C (MyBPC) is a large multi-domain protein whose role in the sarcomere is complex and not yet fully understood. Mutations in MyBPC are strongly associated with the heart disease familial hypertrophic cardiomyopathy (FHC) and these experiments of nature have provided some insight into the intricate workings of this protein in the heart. While some regions of the MyBPC...

Topics

Amino Acid Sequence
Animals
Cardiomyopathy, Hypertrophic, Familial
Carrier Proteins
Humans
Models, Structural
Molecular Sequence Data
Mutation
Myocardium
Protein Binding
Protein Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sarcomeres

Sequence Alignment

Source

Identifiers

PMID: 15115610
DOI: 10.1038/sj.cr.7290208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.PMID 15115610Read ↗

Cardiac myosin binding protein C: its role in physiology and disease.Semantic proximity Read ↗

Cardiac myosin-binding protein C: hypertrophic cardiomyopathy mutations and structure-function relationships.Semantic proximity Read ↗

Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.Semantic proximity Read ↗

Identification of Novel Interactions Between Domains of Myosin Binding Protein-C That Are Modulated by Hypertrophic Cardiomyopathy Missense MutationsSemantic proximity Read ↗

Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes.Semantic proximity Read ↗

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology.Semantic proximity Read ↗

Signaling and myosin-binding protein C.Semantic proximity Read ↗

Bringing into focus the central domains C3-C6 of myosin binding protein CSemantic proximity Read ↗

Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy.Semantic proximity Read ↗

The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C.Semantic proximity Read ↗

Pathogenic <i>MYBPC3</i> missense variants alter protein-protein interactions within the sarcomereSemantic proximity Read ↗

Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.