Article

Pathogenic <i>MYBPC3</i> missense variants alter protein-protein interactions within the sarcomere

2026-05-30

Abstract excerpt

<h4>Background</h4> Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that leads to left ventricular hypertrophy, heart failure, and arrhythmias. Pathogenic missense variants in the gene myosin binding protein C ( MYBPC3) cluster within its internal subdomains C3 and C6. The protein (MyBP-C), carrying these missense variants, localizes normally to the myofilaments, leaving uncertainty regarding the me...

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Literature Corpus work: 1d8967f5-a208-56ef-9d7d-7524cc2444ac
DOI: 10.64898/2026.05.27.727676

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