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Article

Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.

Journal of molecular biology - 25 Apr 2008

Govada Lata, Carpenter Liz, da Fonseca Paula C A, Helliwell John R, Rizkallah Pierre, Flashman Emily, Chayen Naomi E, Redwood Charles, Squire John M

Abstract excerpt

C-protein is a major component of skeletal and cardiac muscle thick filaments. Mutations in the gene encoding cardiac C-protein [cardiac myosin binding protein-C (cMyBP-C)] are one of the principal causes of hypertrophic cardiomyopathy. cMyBP-C is a string of globular domains including eight immunoglobulin-like and three fibronectin-like domains termed C0-C10. It binds to myosin and titin, and probably to actin,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Crystallography, X-Ray

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Source

Identifiers

PMID: 18374358
DOI: 10.1016/j.jmb.2008.02.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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