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Article

Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection.

American journal of human genetics - 1 Jun 2004

Ohashi Jun, Naka Izumi, Patarapotikul Jintana, Hananantachai Hathairad, Brittenham Gary, Looareesuwan Sornchai, Clark Andrew G, Tokunaga Katsushi

Abstract excerpt

The hemoglobin E variant (HbE; ( beta )26Glu-->Lys) is concentrated in parts of Southeast Asia where malaria is endemic, and HbE carrier status has been shown to confer some protection against Plasmodium falciparum malaria. To examine the effect of natural selection on the pattern of linkage disequilibrium (LD) and to infer the evolutionary history of the HbE variant, we analyzed biallelic markers surrounding the...

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Identifiers

PMID: 15114532
DOI: 10.1086/421330
PMCID: PMC1182083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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