Article
Molecular basis of HbE-beta-thalassemia and the origin of HbE in northeast Thailand: identification of one novel mutation using amplified DNA from buffy coat specimens.
Biochemical and biophysical research communications - 31 Jul 1990
Fucharoen G, Fucharoen S, Jetsrisuparb A, Fukumaki Y
Abstract excerpt
Amplification of DNA via polymerase chain reaction directly from a small amount of a buffy coat fraction was used to study the molecular basis of HbE-beta-thalassemia in the northeastern Thai population. Eight different mutations including the new one causing a beta o-thalassemia phenotype were d...
Topics
- Alleles
- Base Sequence
- DNA
- Diagnosis, Differential
- Hemoglobin E
- Hemoglobins, Abnormal
- Hemoglobinuria
- Humans
- Molecular Sequence Data
- Multigene Family
- Mutation
- Polymerase Chain Reaction