Article
Prevalence of HFE mutations among the Thai population and correlation with iron loading in haemoglobin E disorder.
European journal of haematology - 1 Jul 2004
Viprakasit Vip, Vathesathokit Prin, Chinchang Worrawut, Tachavanich Kalaya, Pung-Amritt Parichat, Wimhurst Victoria L C, Yenchitsomanus Pa-Thai, Merryweather-Clarke Alison T, Tanphaichitr Voravarn S
Abstract excerpt
Co-inheritance of HFE mutations has a substantial role in iron overload in beta-thalassaemia carriers in north European populations where two HFE mutations, C282Y and H63D, are prevalent. In Thailand, there was little information about the allele frequency of HFE mutations. It is of interest to determine whether such determinants represent a potential risk in developing iron overload as nearly 40% of the Thai...
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