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Article

Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand.

PloS one - 1 Jan 2014

Ohashi Jun, Suzuki Yuji, Naka Izumi, Hananantachai Hathairad, Patarapotikul Jintana

Abstract excerpt

Sporozoites of Plasmodium falciparum are transmitted to human hosts by Anopheles mosquitoes. Thrombospondin-related adhesive protein (TRAP) is expressed in sporozoites and plays a crucial role in sporozoite gliding and invasion of human hepatocytes. A previous study showed that the TRAP gene has been subjected to balancing selection in the Gambian P. falciparum population. To further study the molecular evolution...

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Identifiers

PMID: 24587387
DOI: 10.1371/journal.pone.0090522
PMCID: PMC3938765

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Source receipt: pubmed, retrieved 7 Sept 2026.

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