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Article

Analysis of the Harvey ras gene in cisplatin-initiated mouse skin tumors by polymerase chain reaction and direct DNA sequencing.

Cancer letters - 31 Jul 1992

Nelson M A, Futscher B W, Loew M R, Bowden G T

Abstract excerpt

Cisplatin (cis-dichlorodiammineplatinum (II)) acts as a tumor initiator in the mouse skin model of carcinogenesis. DNA transfection studies suggested that skin tumors initiated by cisplatin contained dominant transforming activity. Since the Harvey-ras (H-ras) gene is known to be activated by point mutations in chemically initiated mouse skin tumors, we used polymerase chain reaction (PCR) and direct DNA...

Topics

Animals
Base Sequence
Carcinoma, Squamous Cell
Cell Transformation, Neoplastic
Cisplatin
DNA, Neoplasm
Genes, ras
Mice
Molecular Sequence Data
Mutation
Papilloma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Skin Neoplasms

Source

Identifiers

PMID: 1511406
DOI: 10.1016/0304-3835(92)90209-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1511406-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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