Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors

28 Apr 2004

Abstract excerpt

After intravenous administration, adenovirus (Ad) vectors are predominantly sequestered by the liver. Delineating the mechanisms for Ad accumulation in the liver is crucial for a better understanding of Ad clearance and Ad-associated innate toxicity. To help address these issues, in this study, we used Ad vectors with different fiber shaft lengths and either coxsackievirus-Ad receptor (CAR)-interacting Ad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral gastroenteritis research and epidemiology
Share to Viral Infectious Diseases and Gene Expression in Insects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Virus-based gene therapy research

Source

Identifiers

PMID: 15113916
DOI: 10.1128/jvi.78.10.5368-5381.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified VectorsPMID 15113916Read ↗

Two Key Challenges for Effective Adenovirus-Mediated Liver Gene Therapy:Innate Immune Responses and Hepatocyte-Specific TransductionSemantic proximity Read ↗

Fiber Shaft-Chimeric Adenovirus Vectors Lacking the KKTK Motif Efficiently Infect Liver Cells In VivoSemantic proximity Read ↗

Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber.Semantic proximity Read ↗

Advances and Future Challenges in Adenoviral Vector Pharmacology and TargetingSemantic proximity Read ↗

Adeno-associated virus (AAV) capsid engineering in liver-directed gene therapySemantic proximity Read ↗

Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.Semantic proximity Read ↗

Adenovirus receptors: implications for tropism, treatment and targetingSemantic proximity Read ↗

Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytesSemantic proximity Read ↗

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation.Semantic proximity Read ↗

Redundant and synergistic mechanisms control the sequestration of blood-born adenovirus in the liver.Semantic proximity Read ↗

Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates.Semantic proximity Read ↗

Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.