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Impact of liver fibrosis on AAV-mediated gene transfer to mouse hepatocytes

10 Mar 2025

Abstract excerpt

Liver fibrosis, characterized by scar tissue accumulation due to liver injury, poses significant barriers to liver-targeted gene therapy. Current clinical trials exclude patients with fibrosis, as intact liver architecture is considered essential for efficient and safe adeno-associated viral vector (AAV)-mediated gene delivery. Here, we show that liver fibrosis reduces the efficiency of hepatocyte transduction by...

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Share to Viral gastroenteritis research and epidemiology
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PMID: 40064861
DOI: 10.1038/s41467-025-57382-9

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