Article
Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women.
Cancer - 1 Jun 2005
Boyapati Sonia M, Shu Xiao Ou, Gao Yu-Tang, Cai Qiuyin, Jin Fan, Zheng Wei
Abstract excerpt
BACKGROUND: Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS: The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study among Chinese women, the Shanghai Breast Cancer Study. Because the CYP1A1*3 and CYP1A1*4 alleles...
Topics
- Breast Neoplasms
- Case-Control Studies
- China
- Cytochrome P-450 CYP1A1
- Estrogens
- Female
- Genotype
- Homozygote
- Humans
- Menopause
- Middle Aged
- Polymorphism, Genetic