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Article

Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins.

Biochemical and biophysical research communications - 21 May 2004

Huang Yongcheng, Magdaleno Susan, Hopkins Rachel, Slaughter Clive, Curran Tom, Keshvara Lakhu

Abstract excerpt

Disabled 1 (Dab1) functions as a critical adapter protein in the Reelin signaling pathway to direct proper positioning of neurons during brain development. Reelin stimulates phosphorylation of Dab1 on tyrosines 198 and 220, and phosphorylated Dab1 is likely to interact with downstream signaling proteins that contain Src homology 2 (SH2) domains. To search for such proteins, we used a Sepharose-conjugated peptide...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15110774
DOI: 10.1016/j.bbrc.2004.04.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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