Article
Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning.
Genes & development - 15 Mar 1999
Howell B W, Herrick T M, Cooper J A
Abstract excerpt
The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as expected if both genes are in the same pathway. Dab1 is expressed at a higher level, yet...
Topics
- Animals
- Cell Adhesion Molecules, Neuronal
- Extracellular Matrix Proteins
- Gene Expression
- Heterozygote
- Mice
- Mutation
- Nerve Tissue Proteins
- Neurons
- Phosphoproteins
- Phosphorylation
- Reelin Protein
- Serine Endopeptidases
- Signal Transduction
- Tyrosine