Article
Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.
Nature - 16 Oct 1997
Sheldon M, Rice D S, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell B W, Cooper J A, Goldowitz D, Curran T
Abstract excerpt
Formation of the mammalian brain requires choreographed migration of neurons to generate highly ordered laminar structures such as those in the cortices of the forebrain and the cerebellum. These processes are severely disrupted by mutations in reelin which cause widespread misplacement of neurons and associated ataxia in reeler mice. Reelin is a large extracellular protein secreted by pioneer neurons that...
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