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Article

Crystal structures of the Dab homology domains of mouse disabled 1 and 2.

The Journal of biological chemistry - 19 Sept 2003

Yun Mikyung, Keshvara Lakhu, Park Cheon-Gil, Zhang Yong-Mei, Dickerson J Bradley, Zheng Jie, Rock Charles O, Curran Tom, Park Hee-Won

Abstract excerpt

Disabled (Dab) 1 and 2 are mammalian homologues of Drosophila DAB. Dab1 is a key cytoplasmic mediator in Reelin signaling that controls cell positioning in the developing central nervous system, whereas Dab2 is an adapter protein that plays a role in endocytosis. DAB family proteins possess an amino-terminal DAB homology (DH) domain that is similar to the phosphotyrosine binding/phosphotyrosine interaction...

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Identifiers

PMID: 12826668
DOI: 10.1074/jbc.M304384200

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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