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Article

Amino terminal glutamate residues confer spermine sensitivity and affect voltage gating and channel conductance of rat connexin40 gap junctions.

The Journal of physiology - 15 Jun 2004

Musa Hassan, Fenn Edward, Crye Mark, Gemel Joanna, Beyer Eric C, Veenstra Richard D

Abstract excerpt

Connexin40 (Cx40) contains a specific binding site for spermine (affinity approximately 100 microm) whereas connexin43 (Cx43) is unaffected by identical concentrations of intracellular spermine. Replacement of two unique glutamate residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corresponding lysine residues from Cx43 eliminated the block by 2 mm spermine, reduced the...

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Identifiers

PMID: 15107469
DOI: 10.1113/jphysiol.2003.059386
PMCID: PMC1665163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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