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Article

Heterozygous disruption of CMA1 does not affect blood pressure.

Journal of hypertension - 1 Jan 2004

Ono Koh, Kokubo Yoshihiro, Mannami Toshifumi, Inamoto Nozomu, Shioji Keisuke, Iwai Naoharu

Abstract excerpt

OBJECTIVE: It has been suspected that the mast cell chymase gene (CMA1) is important for the generation of angiotensin II and therefore might be associated with the pathogenesis of hypertension. METHODS: We sequenced the promoter region, exons, and exon-intron junctions of CMA1 and found 13 single-nucleotide polymorphisms, two of which were loss-of-function mutations. The loss-of-function mutations resulted in:...

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Source

Identifiers

PMID: 15106801
DOI: 10.1097/00004872-200401000-00019

Genes

CMA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Heterozygous disruption of CMA1 does not affect blood pressure.PMID 15106801Read ↗

Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1.Semantic proximity Read ↗

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A novel (TG)n(GA)m repeat polymorphism 254 bp downstream of the mast cell chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels.Semantic proximity Read ↗

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