Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1.

doi:10.1007/s12265-022-10261-w

Article

Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1.

Journal of cardiovascular translational research - 1 Dec 2022

Fairhurst-Hunter Zammy, Walters Robin G, Zink Alexander, Lin Kuang, Guo Yu, Yu Canqing, Lv Jun, Li Liming, Freitag Daniel F, Chen Zhengming, Millwood Iona Y

Abstract excerpt

Tissue remodelling and fibrosis which occur in response to injury play a central role in the development of many diseases. Chymase is a key enzyme believed to mediate these pathological processes. As such, chymase inhibitors have been under active development for the treatment of a number of conditions. To investigate the impact of reduced chymase function, we constructed a genetic score from two pLoF mutations...

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Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1.

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