Article
Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma.
The Journal of clinical endocrinology and metabolism - 1 Feb 1997
Davies E, Bonnardeaux A, Plouin P F, Corvol P, Clauser E
Abstract excerpt
Angiotensin II stimulates aldosterone secretion from the adrenal zona glomerulosa and mediates most of its biological effects via G protein-coupled type 1 angiotensin II receptors (AT1). A number of G protein-coupled receptors are constitutively activated as a result of somatic mutations in the g...
Topics
- Adenoma
- Adrenal Gland Neoplasms
- Adrenal Glands
- Adult
- Aged
- Aldosterone
- Base Sequence
- Female
- Humans
- Hyperaldosteronism
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptors, Angiotensin
- Reference Values