Article
Association study of mast cell chymase polymorphisms with atopy.
Allergy - 1 Oct 2005
Weidinger S, Rümmler L, Klopp N, Wagenpfeil S, Baurecht H J, Fischer G, Holle R, Gauger A, Schäfer T, Jakob T, Ollert M, Behrendt H, Wichmann H E, Ring J, Illig T
Abstract excerpt
BACKGROUND: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results. METHODS: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with...
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