Article
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2004
Iwanaga T, McEuen A, Walls A F, Clough J B, Keith T P, Rorke S, Barton S J, Holgate S T, Holloway J W
Abstract excerpt
BACKGROUND: Mast cell chymase has the potential to be an important mediator of inflammation and remodelling in the asthmatic lung. Previous studies have examined association between promoter polymorphism of the chymase gene (CMA1) and allergic phenotypes but the significance of this polymorphism is unclear. We have examined association of a CMA1 variant in relation to asthma in a large UK Caucasian family cohort....
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