Article
Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots.
Genetics - 1 Aug 2004
Fearnhead Paul, Harding Rosalind M, Schneider Julie A, Myers Simon, Donnelly Peter
Abstract excerpt
There has been considerable recent interest in understanding the way in which recombination rates vary over small physical distances, and the extent of recombination hotspots, in various genomes. Here we adapt, apply, and assess the power of recently developed coalescent-based approaches to estimating recombination rates from sequence polymorphism data. We apply full-likelihood estimation to study rate variation...
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