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Article

Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat Antagonist

20 Dec 1991

Abstract excerpt

The human immunodeficiency virus-1 (HIV-1) trans-activator Tat is an attractive target for the development of antiviral drugs because inhibition of Tat would arrest the virus at an early stage. The drug Ro 5-3335 [7-chloro-5-(2-pyrryl)-3H-1,4-benzodiazepine-2(H)-one], inhibited gene expression by HIV-1 at the level of transcriptional trans-activation by Tat. The compound did not inhibit the basal activity of the...

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Identifiers

PMID: 1763331
DOI: 10.1126/science.1763331

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