Article
Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.
Antimicrobial agents and chemotherapy - 1 May 2004
Fillet Anne-Marie, Auray Laetitia, Alain Sophie, Gourlain Karine, Imbert Berthe Marie, Najioullah Fatiha, Champier Gael, Gouarin Stéphanie, Carquin Jocelyne, Houhou Nadhira, Garrigue Isabelle, Ducancelle Alexandra, Thouvenot Danielle, Mazeron Marie-Christine
Abstract excerpt
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.