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Article

Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice.

Infection and immunity - 1 May 2004

Iannelli Francesco, Chiavolini Damiana, Ricci Susanna, Oggioni Marco Rinaldo, Pozzi Gianni

Abstract excerpt

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal...

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Share to DNA, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15102826
DOI: 10.1128/IAI.72.5.3077-3080.2004
PMCID: PMC387904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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