Article
A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae.
Research in microbiology - 1 Oct 2014
Zeng Xian-Fei, Ma Yueyun, Yang Liu, Zhou Lei, Xin Yijuan, Chang Liang, Zhang Jing-Ren, Hao Xiaoke
Abstract excerpt
LicC has been identified as a virulence factor of Streptococcus pneumoniae. However, its role in virulence is still not fully understood because deletion of licC is lethal for the bacterium. In this study, a mutant with 78-bp truncation at the C-terminus of licC was obtained from a signature-tagged mutagenesis (STM) library. The mutant was viable with a large reduction in enzymatic activity as CTP:phosphocholine...
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