Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae.

Infection and immunity - 1 Jan 2003

Ren Bing, Szalai Alexander J, Thomas Orlanda, Hollingshead Susan K, Briles David E

Abstract excerpt

Pneumococcal surface protein A (PspA), a virulence factor of Streptococcus pneumoniae, is exceptionally diverse, being classified into two major families which are over 50% divergent by sequence analysis. A family 1 PspA from strain WU2 was previously shown to impede the clearance of pneumococci from mouse blood and to interfere with complement deposition on the bacterial surface. To determine whether a family 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Bacteremia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement Activation

Share to Complement C3

Share to Lactoferrin

Share to Mice, Inbred CBA

Share to Pneumococcal Infections

Share to Streptococcus pneumoniae

Source

Open in PubMed Open full text

Identifiers

PMID: 12496151
DOI: 10.1128/IAI.71.1.75-85.2003
PMCID: PMC143380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae.PMID 12496151Read ↗

Genetic alteration of capsule type but not PspA type affects accessibility of surface-bound complement and surface antigens of Streptococcus pneumoniae.Semantic proximity Read ↗

Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model.Semantic proximity Read ↗

Relative roles of genetic background and variation in PspA in the ability of antibodies to PspA to protect against capsular type 3 and 4 strains of Streptococcus pneumoniae.Semantic proximity Read ↗

The choline-binding proteins PspA, PspC and LytA of <i>Streptococcus pneumoniae</i> and their role on host cellular adhesion and damageSemantic proximity Read ↗

A genetic interaction screen in <i>Streptococcus pneumoniae</i> identifies functionally redundant vaccine candidate proteins CbpC and CbpJSemantic proximity Read ↗

Capsule and PspA Cooperatively Confer Resistance of <i>Streptococcus pneumoniae</i> to the Human defensin HNP-1Semantic proximity Read ↗

Virulence factors in pneumococcal respiratory pathogenesis.Semantic proximity Read ↗

The Effects of PspC on Complement-Mediated Immunity to <i>Streptococcus pneumoniae</i> Vary with Strain Background and Capsular SerotypeSemantic proximity Read ↗

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial SurfaceSemantic proximity Read ↗

Streptococcus pneumoniae PspC Subgroup Prevalence in Invasive Disease and Differences in Contribution to Complement Evasion.Semantic proximity Read ↗

Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.Semantic proximity Read ↗

Requirement for capsule in colonization by Streptococcus pneumoniae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.