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Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.

Vaccine - 10 Mar 2015

Sander Peter, Clark Simon, Petrera Agnese, Vilaplana Cristina, Meuli Michael, Selchow Petra, Zelmer Andrea, Mohanan Deepa, Andreu Nuria, Rayner Emma, Dal Molin Michael, Bancroft Gregory J, Johansen Pål, Cardona Pere-Joan, Williams Ann, Böttger Erik C

Abstract excerpt

Having demonstrated previously that deletion of zinc metalloprotease zmp1 in Mycobacterium bovis BCG increased immunogenicity of BCG vaccines, we here investigated the protective efficacy of BCG zmp1 deletion mutants in a guinea pig model of tuberculosis infection. zmp1 deletion mutants of BCG provided enhanced protection by reducing the bacterial load of tubercle bacilli in the lungs of infected guinea pigs. The...

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PMID: 25657094
DOI: 10.1016/j.vaccine.2015.01.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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