Article
Beijing sublineages of Mycobacterium tuberculosis differ in pathogenicity in the guinea pig.
Clinical and vaccine immunology : CVI - 1 Aug 2012
Kato-Maeda Midori, Shanley Crystal A, Ackart David, Jarlsberg Leah G, Shang Shaobin, Obregon-Henao Andres, Harton Marisabel, Basaraba Randall J, Henao-Tamayo Marcela, Barrozo Joyce C, Rose Jordan, Kawamura L Masae, Coscolla Mireia, Fofanov Viacheslav Y, Koshinsky Heather, Gagneux Sebastien, Hopewell Philip C, Ordway Diane J, Orme Ian M
Abstract excerpt
The Beijing family of Mycobacterium tuberculosis strains is part of lineage 2 (also known as the East Asian lineage). In clinical studies, we have observed that isolates from the sublineage RD207 of lineage 2 were more readily transmitted among humans. To investigate the basis for this difference, we tested representative strains with the characteristic Beijing spoligotype from four of the five sublineages of...
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