Article
Predictive models for breast cancer susceptibility from multiple single nucleotide polymorphisms.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004
Listgarten Jennifer, Damaraju Sambasivarao, Poulin Brett, Cook Lillian, Dufour Jennifer, Driga Adrian, Mackey John, Wishart David, Greiner Russ, Zanke Brent
Abstract excerpt
Hereditary predisposition and causative environmental exposures have long been recognized in human malignancies. In most instances, cancer cases occur sporadically, suggesting that environmental influences are critical in determining cancer risk. To test the influence of genetic polymorphisms on breast cancer risk, we have measured 98 single nucleotide polymorphisms (SNPs) distributed over 45 genes of potential...
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