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Article

Methodological issues in detecting gene-gene interactions in breast cancer susceptibility: a population-based study in Ontario.

BMC medicine - 7 Aug 2007

Briollais Laurent, Wang Yuanyuan, Rajendram Isaac, Onay Venus, Shi Ellen, Knight Julia, Ozcelik Hilmi

Abstract excerpt

BACKGROUND: There is growing evidence that gene-gene interactions are ubiquitous in determining the susceptibility to common human diseases. The investigation of such gene-gene interactions presents new statistical challenges for studies with relatively small sample sizes as the number of potential interactions in the genome can be large. Breast cancer provides a useful paradigm to study genetically complex...

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Identifiers

PMID: 17683639
DOI: 10.1186/1741-7015-5-22
PMCID: PMC1976420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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