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Article

Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2004

Mattison Lori K, Ezzeldin Hany, Carpenter Mark, Modak Anil, Johnson Martin R, Diasio Robert B

Abstract excerpt

PURPOSE: Dihydropyrimidine dehydrogenase (DPD)-deficient cancer patients have been shown to develop severe toxicity after administration of 5-fluorouracil. Routine determination of DPD activity is limited by time-consuming and labor-intensive methods. The purpose of this study was to develop a simple and rapid 2-(13)C-uracil breath test, which could be applied in most clinical settings to detect DPD-deficient...

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Share to Breath Tests
Share to Antimetabolites, Antineoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carbon Dioxide

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Share to Chromatography, High Pressure Liquid

Share to Diagnostic Tests, Routine

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Source

Identifiers

PMID: 15102667
DOI: 10.1158/1078-0432.ccr-03-0374

Genes

DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rapid identification of dihydropyrimidine dehydrogenase deficiency by using a novel 2-13C-uracil breath test.PMID 15102667Read ↗

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