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Article

(13)C-uracil breath test to predict 5-fluorouracil toxicity in gastrointestinal cancer patients.

Cancer chemotherapy and pharmacology - 1 Dec 2013

Cunha-Junior Geraldo Felício, De Marco Luiz, Bastos-Rodrigues Luciana, Bolina Marina Borges, Martins Flavia Linhares, Pianetti Gerson Antonio, Cesar Isabela Costa, Coelho Luiz Gonzaga

Abstract excerpt

PURPOSE: Up to 30 % of patients undergoing 5-fluorouracil (5FU)-based chemotherapy experience severe toxicity. Dihydropyrimidine dehydrogenase (DPD) deficiency explains 36-61 % of cases. Predicting toxicity is an unmet challenge. Uracil breath test (UraBT) consists of measuring (13)CO2 in exhaled...

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Source

Identifiers

PMID: 24101147
DOI: 10.1007/s00280-013-2309-4

Genes

DPYD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24101147-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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