Article
A rapid and inexpensive method for anticipating severe toxicity to fluorouracil and fluorouracil-based chemotherapy.
Therapeutic drug monitoring - 1 Oct 2006
Ciccolini Joseph, Mercier Cédric, Evrard Alexandre, Dahan Laetitia, Boyer Jean-Christophe, Duffaud Florence, Richard Karine, Blanquicett Carmelo, Milano Gérard, Blesius Aurore, Durand Alain, Seitz Jean-François, Favre Roger, Lacarelle Bruno
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD) deficiency leads to dramatic overexposure to fluorouracil (5-FU), resulting in a potentially lethal outcome in patients treated with standard doses. The aim of this study was to validate, in a routine clinical setting, a simple and rapid method to determine the DPD status in a subset of cancer patients, all presenting with life-threatening toxicities following 5-FU or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.