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Article

A comprehensive population-based study comparing the phenotype and genotype in a pretherapeutic screen of dihydropyrimidine dehydrogenase deficiency.

British journal of cancer - 1 Sept 2020

Pallet Nicolas, Hamdane Salma, Garinet Simon, Blons Hélène, Zaanan Aziz, Paillaud Elena, Taieb Julien, Laprevote Olivier, Loriot Marie-Anne, Narjoz Céline

Abstract excerpt

BACKGROUND: Pretherapeutic screening for dihydropyrimidine dehydrogenase (DPD) deficiency is recommended or required prior to the administration of fluoropyrimidine-based chemotherapy. However, the best strategy to identify DPD-deficient patients remains elusive. METHODS: Among a nationwide cohort of 5886 phenotyped patients with cancer who were screened for DPD deficiency over a 3 years period, we assessed the...

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Identifiers

PMID: 32595208
DOI: 10.1038/s41416-020-0962-z
PMCID: PMC7462856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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