[Review of methods for determination of dihydropyrimidine dehydrogenase and possible application in screening previous chemotheraphy with 5-fluorouracil].

Abstract excerpt

5-fluorouracil (5-FU) and its prodrug capecitabine are one of the most commonly used chemotherapeutic drugs. DPD-deficient cancer patients may be at risk of severe and sometimes lethal toxicity after the administration of 5-FU. In 39-61% of the cases severe toxicity of 5-FU is caused by decreased DPD acivity. DPD is the initial and rate-limiting enzyme of the metabolism of pyrimidines. 80-90% of the administered...

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