Article
Identification of DPYD variants and estimation of uracil and dihydrouracil in a healthy Indian population.
Personalized medicine - 1 Jan 2023
Sivamani Poornima, Eriyat Vishnu, Mathew Sumith K, Singh Ashish, Aaron Rekha, Chacko Raju Titus, Joel Anjana, Prabha Ratna, Mathew Binu Susan
Abstract excerpt
Aim: This study aimed to identify DPYD variants and the related but previously unexplored phenotype (plasma uracil, dihydrouracil [DHU], and the DHU-to-uracil ratio) in a healthy adult Indian population. Methods: Healthy adult volunteers (n = 100) had their uracil and DHU levels measured and were genotyped for selected variants. Results: Among the nine variants studied, c.1906-14763G>A and c.85T>C were the most...
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