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Bovine Staphylococcus aureus Superantigens Stimulate the Entire T Cell Repertoire of Cattle

6 Sept 2018

Abstract excerpt

infection. We determined the Vβ T cell activation profile for all functional SAgs encoded by RF122, revealing evidence for bovine host-specific activity among the recently identified RF122-encoded SAgs SElY and SElZ. Remarkably, we discovered that some strains have evolved the capacity to stimulate the entire T cell repertoire of cattle through an array of diverse SAgs, suggesting a key role in bovine immune evasion.

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PMID: 30201699
DOI: 10.1128/iai.00505-18

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