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Article

Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice.

Neuroreport - 1 Mar 2004

Byrne Leah C, Zhou Zhongjun, Tryggvason Karl, Hökfelt Tomas, Fetissov Sergueï O

Abstract excerpt

Membrane-type-1 matrix metalloproteinase (MT1-MMP) knockout (KO) mice fail to gain weight and die 3-4 weeks after birth. To understand the wasting phenotype in MT1-MMP-KO mice we studied the expression of some hypothalamic neuropeptides involved in control of appetite and body weight. In MT1-MMP-KO mice, neuronal perikarya in the arcuate nucleus displayed accumulations of NPY and agouti-related protein (AgRP)...

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Source

Identifiers

PMID: 15094525
DOI: 10.1097/00001756-200403010-00037

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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