Article
The increase in body weight induced by lack of methyl CpG binding protein-2 is associated with altered leptin signalling in the hypothalamus.
Experimental physiology - 1 Sept 2014
Torres-Andrade Rodrigo, Moldenhauer Rodrigo, Gutierrez-Bertín Noemí, Soto-Covasich Jessica, Mancilla-Medina Cristian, Ehrenfeld Carolina, Kerr Bredford
Abstract excerpt
Methyl CpG binding protein-2 (MECP2) is a chromatin-remodelling factor with a dual role in gene expression. Evidence from patients carrying MECP2 mutations and from transgenic mouse models demonstrates that this protein is involved in the control of body weight. However, the mechanism for this has not been fully elucidated. To address this, we used a previously characterized Mecp2-null mouse model and found that...
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